What factors should be focused on in the process of clean engineering design and construction?
The "big problems" such as factory location, general plan design, workshop layout, equipment selection, production and product quality management are important monitoring points in the pharmaceutical production environment. However, in the design and implementation of the purification project, there are some details that need to be done. Otherwise, it is likely that "the Bank of a thousand miles will collapse in the ant nest". The project that costs a lot of money and energy to build will not achieve the expected effect due to the improper air duct or the movement of personnel, which will affect the quality of drugs.
■ air conditioning purification needs to pay attention to energy saving. Air conditioning purification is a large energy consumption household. Energy saving measures need to be paid attention to in design and construction. In the design, the division of system and area, the calculation of air supply volume, the determination of temperature and relative temperature, the determination of cleanliness level and air change frequency, the ratio of fresh air, the heat preservation of air duct, the influence of the bite form in the production of air duct on the air leakage rate, the influence of the connection angle of main pipe and branch pipe on the air flow resistance, whether the flange connection is air leakage, etc., and the selection of air conditioning box, fan, water chiller and other equipment are none One is not related to energy consumption, so these details must be taken into account.
■ the air duct requires both economy and efficiency in the centralized or purified air conditioning system, and the air duct is required to supply air economically and effectively. The former requires low price, convenient construction, low operation cost and small resistance to internal surface smoothness. The latter refers to good tightness, no air leakage, no dust generation, no dust accumulation, no pollution, fire resistance, corrosion resistance and moisture resistance In operation, sometimes the local resistance of pipe fittings is much higher than the resistance along the air duct, which needs to be improved. Pipe fittings mainly include elbow, reducer tee and four-way pipe. The radius of curvature at the center of the bend shall be greater than the side length of the rectangular air duct, and the diameter of the circle shall be 1.25 times. Large section air duct shall be equipped with deflector in the pipe to reduce resistance. In the actual installation and construction, less such treatment. For reducer, it is not allowed to change the diameter suddenly. It is better to be a gradually expanding (shrinking) pipe. The expansion angle of each side of the gradually expanding pipe shall be greater than 15 °, and the contraction angle of each side of the gradually shrinking pipe shall be less than 30 °. The tee of the rectangular air duct shall be bent and divided along the air flow elbow, and the branch pipe shall also have a certain curvature radius. In case of 90 ° angle diversion, a deflector shall be added in the elbow.
■ select the air conditioning box according to the climate conditions, and consider the climate environment. For example, in the north area with low temperature and large dust content in winter, the new air preheating section shall be added to the general air conditioning unit, and the water spraying air treatment mode shall be adopted, so as to wash the air dust and make the heat exchange reach the required temperature and humidity. In the south of China, where the climate is humid and the dust concentration in the air is low, there is no need to preheat the fresh air in winter. The primary filter is used to filter the air and adjust the temperature and humidity. The surface cooling surface regulates the temperature and humidity. It can also strengthen the temperature and humidity reduction process, and then through the intermediate filter and terminal or sub filter. Variable frequency fan is suitable for the matching fan of air conditioning box, which can not only save energy, but also flexibly adjust the air volume and pressure.
■ the automatic control device ensures the whole process adjustment. At present, some manufacturers use the manual way to control the air volume and air pressure. However, because the control valves for controlling the air volume and air pressure are in the technical compartment, and the ceiling is also the soft ceiling of color steel plate, which is basically adjusted during the installation and commissioning. Since then, most of them have not been adjusted, and in fact, they cannot be adjusted. In order to ensure the normal production and work of the clean workshop, a set of relatively complete automatic control device shall be set to realize the following functions: clean room air cleanliness, temperature and humidity, pressure difference monitoring, air valve regulation; temperature, pressure and flow detection of high-purity gas, pure water and circulating cooling water; gas purity, pure water quality monitoring, etc With the increase of operation time, the resistance of the air filter in the purification air conditioning system increases. In order to maintain the air volume, the air valve in the system needs to be adjusted. When the system is started during the unified commissioning, in order to make the fan start without load, it is necessary to close the air valve at the fan outlet. After the fan is started, it is very difficult to open because of the pressure on the air valve. After the change of pressure difference before and after the air filter is used to control the frequency conversion speed regulating device of the fan, the adjustment of the air supply volume will become very easy and the air supply pressure will be stable These monitoring devices can be designed as the measurement and control system of a single system, as well as the distributed computer control and management system. When the fan of purification air conditioning system stops without wind or overtemperature, the electric heater will continue to send electricity for heating, causing equipment damage or even fire. To avoid this situation, the protection of no wind and overtemperature power-off should be set.
■ the fire alarm system is set in the clean workshop to talk with each other, which can reduce people's walking in the clean area, reduce the amount of dust, and create conditions for normal work in case of fire. In addition, a fire alarm system shall be set up to prevent the fire from being easily found outside and causing significant economic losses.
■ multi machine chiller is more flexible. If large cooling capacity is required, single machine should not be selected, multi mechanism should be used, and variable frequency speed regulation should be used for motor to reduce starting power. Multiple machines can be used flexibly, so as not to waste energy phenomenon of "big horse pulling small car".
■ the air conditioning room should be located at the side of the clean room, and its location should be at the side of the clean room, which not only can save energy, but also is conducive to the layout of the air duct, and make the air distribution more reasonable, at the same time, it can save engineering costs.
Shandong ed purification Engineering Co., Ltd. has strong technical strength and construction experience. According to the different needs of clean places, professional equipment is used to form different levels of clean standard space and create the most suitable production and working environment. At present, it has established close cooperation with many enterprises and is a reliable professional purification project implementer. For more knowledge of medical purification industry, please pay attention to WeChat public address: Aide-188 (Ed purify oxygen supply).